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Active immunisation against hepatitis B
Adult: Primary immunisation as recombinant hepatitis B surface antigen: 20 mcg for 3 doses given at 0, 1, and 6 months. Alternatively, or for patients known or presumed exposed to HBV: 20 mcg for 3 doses given at 0, 1, and 2 months followed by a booster at 12 months as accelerated dose schedule. Patient traveling to endemic areas: 20 mcg, given within 1 month prior to departure for 3 doses given at 0, 7, 21 days, followed by a booster at 12 months. As recombinant, adjuvanted hepatitis B surface antigen: 20 mcg for 4 doses given at 0, 1, 2, and 6 months. May be given via SC administration in patients with bleeding disorders.
Child: Primary immunisation as recombinant hepatitis B surface antigen: ≥16 years Same as adult dose. Patient born to HBV-carrier mother: In combination with hepatitis B immunoglobulin: 10 mcg given at 0, 1, 2 and 12 months with 1st dose at birth or within 24 hours of birth. Alternatively, 10 mcg given at 0, 1, 6 months. ≤15 years 10 mcg for 3 doses given at 0, 1, 6 months. Alternatively, 10 mcg for 3 doses given at 0, 1, 2 months followed by a booster at 12 months as accelerated schedule. As recombinant, adjuvanted hepatitis B surface antigen: ≥15 years: Same as adult dose. May be given via SC administration in patients with bleeding disorders.
Child: Primary immunisation as recombinant hepatitis B surface antigen: ≥16 years Same as adult dose. Patient born to HBV-carrier mother: In combination with hepatitis B immunoglobulin: 10 mcg given at 0, 1, 2 and 12 months with 1st dose at birth or within 24 hours of birth. Alternatively, 10 mcg given at 0, 1, 6 months. ≤15 years 10 mcg for 3 doses given at 0, 1, 6 months. Alternatively, 10 mcg for 3 doses given at 0, 1, 2 months followed by a booster at 12 months as accelerated schedule. As recombinant, adjuvanted hepatitis B surface antigen: ≥15 years: Same as adult dose. May be given via SC administration in patients with bleeding disorders.
